Electrospun-nanofibers for Controlled, More Effective Chemotherapy

Electrospinning is the technique in which a high voltage applied across polymer solution enables the production of fibers of thickness in nanofibers, from a few nm to 100s of nm. The polymer solution could be therapeutic for cancer drug delivery, etc. Electro spinning enables to directly engineer Nano fibers that have many advantages as local drug delivery vehicles for therapeutic molecules [1,2], such as high loading capacity, extremely large surface area, porosity, high encapsulation efficiency, ease of modification, combination of two or more drugs, low cost and excellent outcome [3]. They are becoming potential important and versatile class of one dimensional material that has many promising clinical applications including controlled drug delivery for chemotherapy purposes [4]. With suitable components of the solution materials, such as long lasting or slow degrading composites it is possible to have slow release of growth factors and other chemotherapeutic molecules for a sustained release of encapsulated drug molecule for chemotherapy.